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Commentaire de njama

sur Didier Raoult s'est sans doute trompé sur la chloroquine et c'est une excellente nouvelle !


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njama njama 9 avril 2020 10:38

@agent ananas
autres liens vers Chloroquine is a potent inhibitor of SARS coronavirus infection and spread

https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-69
https://www.ncbi.nlm.nih.gov/pubmed/16115318

Cette étude certes réalisée sur des primates vient contredire les conclusions provisoires de Bernard Dugué ("Il se peut que la chloroquine ne soit pas nécessaire mais rien ne permet de le penser en l’état actuel des choses.")
Results
We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.
Conclusion
Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.

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